Wrinkles result from a combination of many factors. It’s not just about cellular changes that can occur over time but also reduction of collagen, or damage caused by free radicals in the sun and the environment. When you frown or concentrate, the muscles between your brows contract, causing your skin to furrow and fold. And when you squint, the muscles around your eyes contract and cause crow’s feet. BOTOX® Cosmetic works beneath the skin’s surface and targets the underlying muscle activity that causes frown lines and crow’s feet. BOTOX® Cosmetic is the only approved treatment to temporarily improve the appearance of both moderate to severe frown lines between the brows and crow’s feet lines in adults. BOTOX® Cosmetic targets one of the underlying causes of frown lines and crow’s feet—the repeated muscle contractions from frowning and squinting over the years. Your specialist will inject these muscles with BOTOX® Cosmetic to temporarily reduce muscle activity. You will begin to notice a visible smoothing of your crow’s feet lines and frown lines between your brows. You may begin to notice results within 24 to 48 hours for moderate to severe frown lines, with results lasting up to 4 months.